5OSC

GLIC-GABAAR alpha1 chimera crystallized in complex with pregnenolone sulfate at pH 4.5

Summary for 5OSC

Entry DOI	10.2210/pdb5osc/pdb
Descriptor	Proton-gated ion channel,Gamma-aminobutyric acid receptor subunit alpha-2,Gamma-aminobutyric acid receptor subunit alpha-1, ACETATE ION, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	gabaa-receptor ion channel ion transport extracellular ligand gated ion channel, transport protein
Biological source	Gloeobacter violaceus (strain PCC 7421) More
Cellular location	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein: P62812
Total number of polymer chains	5
Total formula weight	198286.85
Authors	Laverty, D.C.,Gold, M.G.,Smart, T.G. (deposition date: 2017-08-17, release date: 2017-10-11, Last modification date: 2024-01-17)
Primary citation	Laverty, D.,Thomas, P.,Field, M.,Andersen, O.J.,Gold, M.G.,Biggin, P.C.,Gielen, M.,Smart, T.G. Crystal structures of a GABAA-receptor chimera reveal new endogenous neurosteroid-binding sites. Nat. Struct. Mol. Biol., 24:977-985, 2017 Cited by PubMed: 28967882 DOI: 10.1038/nsmb.3477 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation