5OSC
GLIC-GABAAR alpha1 chimera crystallized in complex with pregnenolone sulfate at pH 4.5
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | Proton-gated ion channel,Gamma-aminobutyric acid receptor subunit alpha-2,Gamma-aminobutyric acid receptor subunit alpha-1 | polymer | 336 | 38644.2 | 5 | UniProt (Q7NDN8) UniProt (P26048) UniProt (P62812) Pfam (PF02931) Pfam (PF02932) | Gloeobacter violaceus (strain PCC 7421) | GLIC,Ligand-gated ion channel,LGIC,GABA(A) receptor subunit alpha-2,GABA(A) receptor subunit alpha-1 |
| 2 | F, J, K, P, S... (A, B, C, D, E) | ACETATE ION | non-polymer | 59.0 | 8 | Chemie (ACT) PubChem (175) | |||
| 3 | G, L, Q, U, Z (A, B, C, D, E) | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) PubChem (312) | |||
| 4 | AA, H, M, R, V (E, A, B, C, D) | Pregnenolone sulfate | non-polymer | 396.5 | 5 | Chemie (A8W) PubChem (20845972) PubChem (4903) PubChem (105074) PubChem (44263373) PubChem (53761718) PubChem (57347247) PubChem (6602452) PubChem (6604147) PubChem (9802139) PubChem (9952629) PubChem (10668470) PubChem (124303475) PubChem (162948113) PubChem (162948114) PubChem (162948115) | |||
| 5 | BA, I, N, O, W (E, A, B, D) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 5 | Chemie (Y01) PubChem (16219150) PubChem (22210610) PubChem (65082) PubChem (363416) PubChem (45489984) PubChem (500055) PubChem (60078761) PubChem (57163942) PubChem (73440805) PubChem (89891013) PubChem (13301926) PubChem (13301927) PubChem (99567469) PubChem (99567468) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (11969853) PubChem (124301053) PubChem (124302591) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (137392566) PubChem (137496323) PubChem (124914595) PubChem (124914596) PubChem (131705526) PubChem (155804219) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (169132514) PubChem (154929912) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028) |
Sequence modifications
A, B, C, D, E: 1 - 193 (UniProt: Q7NDN8)
A, B, C, D, E: 223 - 311 (UniProt: P26048)
A, B, C, D, E: 390 - 428 (UniProt: P62812)
A, B, C, D, E: 223 - 311 (UniProt: P26048)
| PDB | External Database | Details |
|---|---|---|
| Val 258 | Gly 286 | conflict |
| Ser 312 | - | linker |
| Gln 313 | - | linker |
| Pro 314 | - | linker |
| Ala 315 | - | linker |
| Arg 316 | - | linker |
| Ala 317 | - | linker |
| Ala 318 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| His 429 | - | expression tag |
| His 430 | - | expression tag |
| His 431 | - | expression tag |
| His 432 | - | expression tag |
| His 433 | - | expression tag |
| His 434 | - | expression tag |
| His 435 | - | expression tag |
| His 436 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 193220.9 | |
| Non-Polymers* | Number of molecules | 23 |
| Total formula weight | 5066.0 | |
| All* | Total formula weight | 198286.9 |
