5OR9
Crystal Structure of BAZ2B bromodomain in complex with 1-methyl-cyclopentapyrazole compound 13
Summary for 5OR9
Entry DOI | 10.2210/pdb5or9/pdb |
Related | 5OR8 |
Descriptor | Bromodomain adjacent to zinc finger domain protein 2B, (2~{S})-1-(4-fluorophenyl)sulfonyl-~{N}-(2-methyl-5,6-dihydro-4~{H}-cyclopenta[c]pyrazol-3-yl)pyrrolidine-2-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | four helical bundle, transcription |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : Q9UIF8 |
Total number of polymer chains | 1 |
Total formula weight | 14073.17 |
Authors | Lolli, G.,Vedove, A.D.,Marchand, J.-R.,Caflisch, A. (deposition date: 2017-08-15, release date: 2017-09-13, Last modification date: 2024-01-17) |
Primary citation | Marchand, J.R.,Dalle Vedove, A.,Lolli, G.,Caflisch, A. Discovery of Inhibitors of Four Bromodomains by Fragment-Anchored Ligand Docking. J Chem Inf Model, 57:2584-2597, 2017 Cited by PubMed: 28862840DOI: 10.1021/acs.jcim.7b00336 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report