5O4S

Crystal structure of the human BRPF1 bromodomain in complex with BZ135

Summary for 5O4S

DescriptorPeregrin, ~{N}-[1,4-dimethyl-7-morpholin-4-yl-2,3-bis(oxidanylidene)quinoxalin-6-yl]-5,6,7,8-tetrahydronaphthalene-2-sulfonamide, NITRATE ION, ... (4 entities in total)
Functional Keywordsbromodomain and phd finger-containing protein 1(brpf1), monocytic leukemia zinc-finger (moz), inhibitor, transcription, dna binding protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight28438.54
Authors
Zhu, J.,Caflisch, A. (deposition date: 2017-05-30, release date: 2018-06-13)
Primary citation
Zhu, J.,Caflisch, A.
Crystal structure of the human BRPF1 bromodomain in complex with BZ135
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.75 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.222301.0%2.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5o4s
no rotation
Molmil generated image of 5o4s
rotated about x axis by 90°
Molmil generated image of 5o4s
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 5o4s
no rotation
Molmil generated image of 5o4s
rotated about x axis by 90°
Molmil generated image of 5o4s
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (5o4s.pdb1.gz [45.11 KB])
Coordinate files for Biological unit (5o4s.pdb2.gz [44.41 KB])
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