5O4S
Crystal structure of the human BRPF1 bromodomain in complex with BZ135
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue 9KW A 801 |
| Chain | Residue |
| A | ILE652 |
| A | HOH915 |
| A | HOH931 |
| B | LYS639 |
| A | PHE653 |
| A | PRO658 |
| A | GLU661 |
| A | VAL662 |
| A | CYS704 |
| A | TYR707 |
| A | ASN708 |
| A | PHE714 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue NO3 A 802 |
| Chain | Residue |
| A | GLU694 |
| A | LEU729 |
| A | ARG733 |
| B | ASP691 |
| B | ARG733 |
| B | HOH918 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue 9KW B 801 |
| Chain | Residue |
| A | LYS639 |
| B | ILE652 |
| B | PRO658 |
| B | GLU661 |
| B | VAL662 |
| B | CYS704 |
| B | TYR707 |
| B | ASN708 |
| B | PHE714 |
| B | HOH911 |
| B | HOH930 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 58 |
| Details | BROMODOMAIN_1 Bromodomain signature. GniFsepvPlsevp..DYLdhIkkpMdfftMkqnleayr..Ylnfddfeedfnl.IvsNClkY |
| Chain | Residue | Details |
| A | GLY650-TYR707 |
