5O1S

Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases

Summary for 5O1S

• Entry DOI: 10.2210/pdb5o1s/pdb
• Descriptor: Ribosomal protein S6 kinase alpha-3, SODIUM ION, Dimethyl fumarate, ... (4 entities in total)
• Functional Keywords: covalent, inhibitor, kinase, allosteric, transferase
• Biological source: Mus musculus (Mouse)
• Total number of polymer chains: 1
• Total formula weight: 41557.10

Authors

Andersen, J.L.,Nissen, P. (deposition date: 2017-05-19, release date: 2018-05-30, Last modification date: 2024-01-17)

• Primary citation: Andersen, J.L.,Gesser, B.,Funder, E.D.,Nielsen, C.J.F.,Gotfred-Rasmussen, H.,Rasmussen, M.K.,Toth, R.,Gothelf, K.V.,Arthur, J.S.C.,Iversen, L.,Nissen, P.; Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases.; Nat Commun, 9:4344-4344, 2018; PubMed: 30341347; DOI: 10.1038/s41467-018-06787-w

Experimental method

X-RAY DIFFRACTION (1.9 Å)