5O1S
Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Ribosomal protein S6 kinase alpha-3 | polymer | 364 | 41241.8 | 1 | UniProt (P18654) Pfam (PF00069) In PDB | Mus musculus (Mouse) | S6K-alpha-3,90 kDa ribosomal protein S6 kinase 3,p90RSK3,MAP kinase-activated protein kinase 1b,MAPKAPK-1b,Ribosomal S6 kinase 2,RSK-2,pp90RSK2 |
2 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
3 | A | Dimethyl fumarate | non-polymer | 146.1 | 2 | Chemie (9HB) | |||
4 | water | water | 18.0 | 101 | Chemie (HOH) |
Sequence modifications
A: 400 - 740 (UniProt: P18654)
PDB | External Database | Details |
---|---|---|
Met 377 | - | initiating methionine |
His 378 | - | expression tag |
His 379 | - | expression tag |
His 380 | - | expression tag |
His 381 | - | expression tag |
His 382 | - | expression tag |
His 383 | - | expression tag |
His 384 | - | expression tag |
His 385 | - | expression tag |
Asp 386 | - | expression tag |
Tyr 387 | - | expression tag |
Asp 388 | - | expression tag |
Ile 389 | - | expression tag |
Pro 390 | - | expression tag |
Thr 391 | - | expression tag |
Thr 392 | - | expression tag |
Glu 393 | - | expression tag |
Asn 394 | - | expression tag |
Leu 395 | - | expression tag |
Tyr 396 | - | expression tag |
Phe 397 | - | expression tag |
Gln 398 | - | expression tag |
Gly 399 | - | expression tag |
Glu 591 | Lys 591 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 41241.8 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 315.3 | |
All* | Total formula weight | 41557.1 |