5NX2

Crystal structure of thermostabilised full-length GLP-1R in complex with a truncated peptide agonist at 3.7 A resolution

Summary for 5NX2

Entry DOI	10.2210/pdb5nx2/pdb
Descriptor	Glucagon-like peptide 1 receptor, truncated peptide agonist, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	7tm, gpcr, signalling protein, membrane protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	52088.24
Authors	Rappas, M.,Jazayeri, A.,Brown, A.J.H.,Kean, J.,Errey, J.C.,Robertson, N.,Fiez-Vandal, C.,Andrews, S.P.,Congreve, M.,Bortolato, A.,Mason, J.S.,Baig, A.H.,Teobald, I.,Dore, A.S.,Weir, M.,Cooke, R.M.,Marshall, F.H. (deposition date: 2017-05-09, release date: 2017-06-14, Last modification date: 2024-01-17)
Primary citation	Jazayeri, A.,Rappas, M.,Brown, A.J.H.,Kean, J.,Errey, J.C.,Robertson, N.J.,Fiez-Vandal, C.,Andrews, S.P.,Congreve, M.,Bortolato, A.,Mason, J.S.,Baig, A.H.,Teobald, I.,Dore, A.S.,Weir, M.,Cooke, R.M.,Marshall, F.H. Crystal structure of the GLP-1 receptor bound to a peptide agonist. Nature, 546:254-258, 2017 Cited by PubMed: 28562585 DOI: 10.1038/nature22800 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.7 Å)

Structure validation