5NX2
Crystal structure of thermostabilised full-length GLP-1R in complex with a truncated peptide agonist at 3.7 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0004967 | molecular_function | glucagon receptor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007165 | biological_process | signal transduction |
| A | 0007166 | biological_process | cell surface receptor signaling pathway |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| A | 0007190 | biological_process | activation of adenylate cyclase activity |
| A | 0007204 | biological_process | positive regulation of cytosolic calcium ion concentration |
| A | 0007611 | biological_process | learning or memory |
| A | 0008016 | biological_process | regulation of heart contraction |
| A | 0008528 | molecular_function | G protein-coupled peptide receptor activity |
| A | 0016020 | cellular_component | membrane |
| A | 0017046 | molecular_function | peptide hormone binding |
| A | 0031204 | biological_process | post-translational protein targeting to membrane, translocation |
| A | 0038023 | molecular_function | signaling receptor activity |
| A | 0044508 | molecular_function | glucagon-like peptide 1 receptor activity |
| A | 0045776 | biological_process | negative regulation of blood pressure |
| A | 0045777 | biological_process | positive regulation of blood pressure |
| A | 0046879 | biological_process | hormone secretion |
| A | 0065008 | biological_process | regulation of biological quality |
| A | 0071377 | biological_process | cellular response to glucagon stimulus |
| A | 1990911 | biological_process | response to psychosocial stress |
Functional Information from PROSITE/UniProt
| site_id | PS00649 |
| Number of Residues | 25 |
| Details | G_PROTEIN_RECEP_F2_1 G-protein coupled receptors family 2 signature 1. CnrtFDeya.CWpdGepgsfvnvsCP |
| Chain | Residue | Details |
| A | CYS62-PRO86 |
| site_id | PS00650 |
| Number of Residues | 16 |
| Details | G_PROTEIN_RECEP_F2_2 G-protein coupled receptors family 2 signature 2. QGLMVaILYCFaNneV |
| Chain | Residue | Details |
| A | GLN394-VAL409 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 166 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:28514449 |
| Chain | Residue | Details |
| A | ARG24-GLU139 | |
| A | LYS202-ARG227 | |
| A | TYR291-TYR305 | |
| A | MET371-LYS383 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:28514449 |
| Chain | Residue | Details |
| A | GLN140-ALA164 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 42 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:28514449 |
| Chain | Residue | Details |
| A | ILE165-THR175 | |
| A | TYR252-ILE265 | |
| A | ALA329-ARG348 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:28514449 |
| Chain | Residue | Details |
| A | ARG176-LEU201 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:28514449 |
| Chain | Residue | Details |
| A | LEU228-LEU251 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:28514449 |
| Chain | Residue | Details |
| A | PHE266-LEU290 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:28514449 |
| Chain | Residue | Details |
| A | TRP306-ILE328 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:28514449 |
| Chain | Residue | Details |
| A | LEU349-VAL370 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:28514449 |
| Chain | Residue | Details |
| A | LEU384-PHE404 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | SITE: Interaction with the endogenous ligand GLP-1 => ECO:0000269|PubMed:19861722 |
| Chain | Residue | Details |
| A | ARG121 | |
| A | GLU128 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: ADP-ribosylcysteine => ECO:0000269|PubMed:21901419 |
| Chain | Residue | Details |
| A | CYS341 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | MOD_RES: ADP-ribosylarginine => ECO:0000269|PubMed:21901419 |
| Chain | Residue | Details |
| A | ARG348 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22412906 |
| Chain | Residue | Details |
| A | ASN63 | |
| A | ASN82 | |
| A | ASN115 |
