5NSD
Co-crystal structure of NAMPT dimer with KPT-9274
Summary for 5NSD
Entry DOI | 10.2210/pdb5nsd/pdb |
Descriptor | Nicotinamide phosphoribosyltransferase, PHOSPHATE ION, GLYCEROL, ... (5 entities in total) |
Functional Keywords | drug target, nampt, crispr/cas, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P43490 |
Total number of polymer chains | 2 |
Total formula weight | 115480.08 |
Authors | Neggers, J.E.,Kwanten, B.,Dierckx, T.,Noguchi, H.,Voet, A.,Vercruysse, T.,Baloglu, E.,Senapedis, W.,Jacquemyn, M.,Daelemans, D. (deposition date: 2017-04-26, release date: 2018-02-14, Last modification date: 2024-05-08) |
Primary citation | Neggers, J.E.,Kwanten, B.,Dierckx, T.,Noguchi, H.,Voet, A.,Bral, L.,Minner, K.,Massant, B.,Kint, N.,Delforge, M.,Vercruysse, T.,Baloglu, E.,Senapedis, W.,Jacquemyn, M.,Daelemans, D. Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes. Nat Commun, 9:502-502, 2018 Cited by PubMed: 29402884DOI: 10.1038/s41467-017-02349-8 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.046 Å) |
Structure validation
Download full validation report