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5NFN

JMJD7 IN COMPLEX WITH MN AND 2OG IN THE H32 FORM

Summary for 5NFN
Entry DOI10.2210/pdb5nfn/pdb
Related5FNO
DescriptorJmjC domain-containing protein 7, MANGANESE (II) ION, 2-OXOGLUTARIC ACID, ... (6 entities in total)
Functional Keywordsoxidoreductase, non-heme, iron, 2-oxoglutarate, dioxygenase, oxygenase, jmjc, jmjc domain, jmjc domain-containing protein 7, jmjd7, jmjc hydroxylase, jmjc demethylase, kdms, post-translational modifications, ptm, hydroxylation, lysyl hydroxylation, dimerisation, translation factor, developmentally regulated gtp binding proteins, drg1, drg2, trafac gtpase, hypoxia, nucleic acid-binding, metal-binding, translation, helix-loop-helix-beta, dsbh, facial triad, development, cancer, ribosome biogenesis
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total formula weight153492.97
Authors
Chowdhury, R.,Markolovic, S.,Schofield, C.J. (deposition date: 2017-03-14, release date: 2018-03-14, Last modification date: 2019-06-12)
Primary citationMarkolovic, S.,Zhuang, Q.,Wilkins, S.E.,Eaton, C.,Katz, M.J.,Smith, H.E.,Lesniak, R.K.,Hall, C.,Struwe, W.B.,Konietzny, R.,Davis, S.,Yang, M.,Ge, W.,Benesch, J.L.,Kessler, B.M.,Ratcliffe, P.J.,Cockman, M.E.,Fischer, R.,Wappner, P.,Chowdhury, R.,Coleman, M.L.,Schofield, C.J.
(3S)-Lysyl hydroxylation of TRAFAC GTPases is catalyzed by the human Jumonji-C oxygenase JMJD7.
To Be Published,
Experimental method
X-RAY DIFFRACTION (2.982 Å)
Structure validation

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