5N16
First Bromodomain (BD1) from Candida albicans Bdf1 bound to a dibenzothiazepinone (compound 1)
Summary for 5N16
| Entry DOI | 10.2210/pdb5n16/pdb |
| Descriptor | Bromodomain-containing factor 1, 5-cyclopropyl-2-(5-pyrazin-2-yl-1,2,4-oxadiazol-3-yl)benzo[b][1,4]benzothiazepin-6-one, NICKEL (II) ION, ... (5 entities in total) |
| Functional Keywords | bromodomain, transcription |
| Biological source | Candida albicans (Yeast) |
| Cellular location | Nucleus : Q5A4W8 |
| Total number of polymer chains | 4 |
| Total formula weight | 63947.09 |
| Authors | Mietton, F.,Ferri, E.,Champleboux, M.,Zala, N.,Maubon, D.,Zhou, Y.,Harbut, M.,Spittler, D.,Garnaud, C.,Courcon, M.,Chauvel, M.,d'Enfert, C.,Kashemirov, B.A.,Hull, M.,Cornet, M.,McKenna, C.E.,Govin, J.,Petosa, C. (deposition date: 2017-02-05, release date: 2017-05-31, Last modification date: 2024-01-17) |
| Primary citation | Mietton, F.,Ferri, E.,Champleboux, M.,Zala, N.,Maubon, D.,Zhou, Y.,Harbut, M.,Spittler, D.,Garnaud, C.,Courcon, M.,Chauvel, M.,d'Enfert, C.,Kashemirov, B.A.,Hull, M.,Cornet, M.,McKenna, C.E.,Govin, J.,Petosa, C. Selective BET bromodomain inhibition as an antifungal therapeutic strategy. Nat Commun, 8:15482-15482, 2017 Cited by PubMed: 28516956DOI: 10.1038/ncomms15482 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.76 Å) |
Structure validation
Download full validation report
