5MYM

Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound GSK2032710A at 2.28A resolution

Summary for 5MYM

Entry DOI	10.2210/pdb5mym/pdb
Descriptor	HTH-type transcriptional regulator EthR, [4-(phenylmethyl)piperidin-1-yl]-[1-(5-pyrrol-1-yl-1,3,4-thiadiazol-2-yl)piperidin-4-yl]methanone, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	ethr, mycobacterium tuberculosis, transcription, represor
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains	4
Total formula weight	102156.46
Authors	Mendes, V.,Blaszczyk, M.,Mugumbate, G.,Blundell, T.L. (deposition date: 2017-01-27, release date: 2017-10-25, Last modification date: 2024-01-17)
Primary citation	Mugumbate, G.,Mendes, V.,Blaszczyk, M.,Sabbah, M.,Papadatos, G.,Lelievre, J.,Ballell, L.,Barros, D.,Abell, C.,Blundell, T.L.,Overington, J.P. Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach. Front Pharmacol, 8:681-681, 2017 Cited by PubMed: 29018348 DOI: 10.3389/fphar.2017.00681 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.28 Å)

Structure validation