5MYM
Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound GSK2032710A at 2.28A resolution
Summary for 5MYM
Entry DOI | 10.2210/pdb5mym/pdb |
Descriptor | HTH-type transcriptional regulator EthR, [4-(phenylmethyl)piperidin-1-yl]-[1-(5-pyrrol-1-yl-1,3,4-thiadiazol-2-yl)piperidin-4-yl]methanone, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | ethr, mycobacterium tuberculosis, transcription, represor |
Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Total number of polymer chains | 4 |
Total formula weight | 102156.46 |
Authors | Mendes, V.,Blaszczyk, M.,Mugumbate, G.,Blundell, T.L. (deposition date: 2017-01-27, release date: 2017-10-25, Last modification date: 2024-01-17) |
Primary citation | Mugumbate, G.,Mendes, V.,Blaszczyk, M.,Sabbah, M.,Papadatos, G.,Lelievre, J.,Ballell, L.,Barros, D.,Abell, C.,Blundell, T.L.,Overington, J.P. Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach. Front Pharmacol, 8:681-681, 2017 Cited by PubMed: 29018348DOI: 10.3389/fphar.2017.00681 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.28 Å) |
Structure validation
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