5MYM
Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound GSK2032710A at 2.28A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | HTH-type transcriptional regulator EthR | polymer | 228 | 25259.3 | 4 | UniProt (P9WMC1) Pfam (PF00440) Pfam (PF21313) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | |
| 2 | E, H (B, C) | [4-(phenylmethyl)piperidin-1-yl]-[1-(5-pyrrol-1-yl-1,3,4-thiadiazol-2-yl)piperidin-4-yl]methanone | non-polymer | 435.6 | 2 | Chemie (HYV) | |||
| 3 | F, G, I, J (B, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 4 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 254 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 216 (UniProt: P9WMC1)
| PDB | External Database | Details |
|---|---|---|
| Met -3 | - | initiating methionine |
| Asp -2 | - | expression tag |
| Ile -1 | - | expression tag |
| Glu 0 | - | expression tag |
| Phe 1 | Met 1 | conflict |
| Gly 217 | - | expression tag |
| Ser 218 | - | expression tag |
| His 219 | - | expression tag |
| His 220 | - | expression tag |
| His 221 | - | expression tag |
| His 222 | - | expression tag |
| His 223 | - | expression tag |
| His 224 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 101037.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1119.4 | |
| All* | Total formula weight | 102156.5 |
