5MYM
Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound GSK2032710A at 2.28A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000976 | molecular_function | transcription cis-regulatory region binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0046677 | biological_process | response to antibiotic |
| B | 0000976 | molecular_function | transcription cis-regulatory region binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| B | 0046677 | biological_process | response to antibiotic |
| C | 0000976 | molecular_function | transcription cis-regulatory region binding |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003700 | molecular_function | DNA-binding transcription factor activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005829 | cellular_component | cytosol |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| C | 0046677 | biological_process | response to antibiotic |
| D | 0000976 | molecular_function | transcription cis-regulatory region binding |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003700 | molecular_function | DNA-binding transcription factor activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005829 | cellular_component | cytosol |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| D | 0046677 | biological_process | response to antibiotic |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue HYV B 301 |
| Chain | Residue |
| B | GLY106 |
| B | TYR148 |
| B | THR149 |
| B | ASN176 |
| B | ASN179 |
| B | GLU180 |
| B | LEU183 |
| B | PHE184 |
| B | EDO302 |
| B | ILE107 |
| B | PHE110 |
| B | PHE114 |
| B | GLY124 |
| B | GLN125 |
| B | ARG128 |
| B | TRP138 |
| B | MET142 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 302 |
| Chain | Residue |
| B | GLN125 |
| B | GLU180 |
| B | ARG181 |
| B | PHE184 |
| B | HYV301 |
| B | HOH415 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 303 |
| Chain | Residue |
| B | ALA168 |
| B | HIS169 |
| B | HOH401 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | binding site for residue HYV C 301 |
| Chain | Residue |
| C | GLY106 |
| C | ILE107 |
| C | PHE110 |
| C | PHE114 |
| C | GLY124 |
| C | GLN125 |
| C | ARG128 |
| C | TRP138 |
| C | MET142 |
| C | THR149 |
| C | ASN176 |
| C | ASN179 |
| C | GLU180 |
| C | LEU183 |
| C | PHE184 |
| C | TRP207 |
| C | EDO303 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 302 |
| Chain | Residue |
| C | PRO167 |
| C | ALA168 |
| C | HIS169 |
| C | HOH401 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 303 |
| Chain | Residue |
| C | GLN125 |
| C | GLU180 |
| C | ARG181 |
| C | PHE184 |
| C | HYV301 |
| C | HOH417 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 76 |
| Details | DNA_BIND: H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00335 |
| Chain | Residue | Details |
| A | SER46-PHE65 | |
| B | SER46-PHE65 | |
| C | SER46-PHE65 | |
| D | SER46-PHE65 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | SITE: Inhibitor-binding |
| Chain | Residue | Details |
| A | ASN176 | |
| A | ASN179 | |
| B | ASN176 | |
| B | ASN179 | |
| C | ASN176 | |
| C | ASN179 | |
| D | ASN176 | |
| D | ASN179 |
