5MSB
Crystal structure of human carbonic anhydrase isozyme XII with 2,3,5,6-tetrafluoro-4[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
Summary for 5MSB
Entry DOI | 10.2210/pdb5msb/pdb |
Related | 5LLC 5LLE 5LLG 5LLH 5LLN 5LLO 5LLP 5MSA |
Descriptor | Carbonic anhydrase 12, ZINC ION, 1,2-ETHANEDIOL, ... (6 entities in total) |
Functional Keywords | drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor complex, lyase |
Biological source | Homo sapiens (Human) |
Cellular location | Membrane; Single-pass type I membrane protein: O43570 |
Total number of polymer chains | 4 |
Total formula weight | 121758.51 |
Authors | Smirnov, A.,Manakova, E.,Grazulis, S. (deposition date: 2017-01-02, release date: 2018-01-17, Last modification date: 2024-01-17) |
Primary citation | Smirnov, A.,Zubriene, A.,Manakova, E.,Grazulis, S.,Matulis, D. Crystal structure correlations with the intrinsic thermodynamics of human carbonic anhydrase inhibitor binding. PeerJ, 6:e4412-e4412, 2018 Cited by PubMed: 29503769DOI: 10.7717/peerj.4412 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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