5LLC

Crystal structure of human carbonic anhydrase isozyme II with 3-(Methylamino)-2,5,6-trifluoro-4-[(2-phenylethyl)sulfonyl]benzenesulfonamide

Summary for 5LLC

Entry DOI	10.2210/pdb5llc/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, DIMETHYL SULFOXIDE, ... (6 entities in total)
Functional Keywords	drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor complex, lyase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	30167.43
Authors	Manakova, E.,Smirnov, A.,Grazulis, S. (deposition date: 2016-07-27, release date: 2017-08-16, Last modification date: 2024-01-10)
Primary citation	Smirnov, A.,Zubriene, A.,Manakova, E.,Grazulis, S.,Matulis, D. Crystal structure correlations with the intrinsic thermodynamics of human carbonic anhydrase inhibitor binding. PeerJ, 6:e4412-e4412, 2018 Cited by PubMed: 29503769 DOI: 10.7717/peerj.4412 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.1 Å)

Structure validation