5LLH
Crystal structure of human carbonic anhydrase isozyme II with 4-(1,3-Benzothiazol-2-ylthio)-2,3,5,6-tetrafluorobenzenesulfonamide
Summary for 5LLH
| Entry DOI | 10.2210/pdb5llh/pdb |
| Descriptor | Carbonic anhydrase 2, ZINC ION, 4-(1,3-benzothiazol-2-ylsulfanyl)-2,3,5,6-tetrakis(fluoranyl)benzenesulfonamide, ... (7 entities in total) |
| Functional Keywords | drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor complex, lyase |
| Biological source | Homo sapiens (Human) |
| Cellular location | Cytoplasm : P00918 |
| Total number of polymer chains | 1 |
| Total formula weight | 30263.53 |
| Authors | Manakova, E.,Smirnov, A.,Grazulis, S. (deposition date: 2016-07-27, release date: 2017-08-16, Last modification date: 2024-01-10) |
| Primary citation | Smirnov, A.,Zubriene, A.,Manakova, E.,Grazulis, S.,Matulis, D. Crystal structure correlations with the intrinsic thermodynamics of human carbonic anhydrase inhibitor binding. PeerJ, 6:e4412-e4412, 2018 Cited by PubMed: 29503769DOI: 10.7717/peerj.4412 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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