5MQJ

Crystal structure of dCK mutant C3S

Summary for 5MQJ

• Entry DOI: 10.2210/pdb5mqj/pdb
• Descriptor: Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ... (4 entities in total)
• Functional Keywords: deoxycytidine kinase, dck, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : P27707
• Total number of polymer chains: 4
• Total formula weight: 135106.98

Authors

Saez-Ayala, M.,Rebuffet, E.,Hammam, K.,Gros, L.,Lopez, S.,Hajem, B.,Humbert, M.,Baudelet, E.,Audebert, S.,Betzi, S.,Lugari, A.,Combes, S.,Pez, D.,Letard, S.,Mansfield, C.,Moussy, A.,de Sepulveda, P.,Morelli, X.,Dubreuil, P. (deposition date: 2016-12-20, release date: 2017-11-22, Last modification date: 2024-01-17)

• Primary citation: Hammam, K.,Saez-Ayala, M.,Rebuffet, E.,Gros, L.,Lopez, S.,Hajem, B.,Humbert, M.,Baudelet, E.,Audebert, S.,Betzi, S.,Lugari, A.,Combes, S.,Letard, S.,Casteran, N.,Mansfield, C.,Moussy, A.,De Sepulveda, P.,Morelli, X.,Dubreuil, P.; Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology.; Nat Commun, 8:1420-1420, 2017; PubMed: 29127277; DOI: 10.1038/s41467-017-01582-5

Experimental method

X-RAY DIFFRACTION (3.7 Å)