Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5MQJ

Crystal structure of dCK mutant C3S

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004136	molecular_function	deoxyadenosine kinase activity
A	0004137	molecular_function	deoxycytidine kinase activity
A	0004138	molecular_function	deoxyguanosine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0006170	biological_process	dAMP biosynthetic process
A	0006220	biological_process	pyrimidine nucleotide metabolic process
A	0008144	molecular_function	obsolete drug binding
A	0009157	biological_process	deoxyribonucleoside monophosphate biosynthetic process
A	0009224	biological_process	CMP biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0019136	molecular_function	deoxynucleoside kinase activity
A	0032261	biological_process	purine nucleotide salvage
A	0042803	molecular_function	protein homodimerization activity
A	0043771	molecular_function	cytidine kinase activity
A	1901135	biological_process	carbohydrate derivative metabolic process
A	1901293	biological_process	nucleoside phosphate biosynthetic process
B	0000166	molecular_function	nucleotide binding
B	0004136	molecular_function	deoxyadenosine kinase activity
B	0004137	molecular_function	deoxycytidine kinase activity
B	0004138	molecular_function	deoxyguanosine kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006139	biological_process	nucleobase-containing compound metabolic process
B	0006170	biological_process	dAMP biosynthetic process
B	0006220	biological_process	pyrimidine nucleotide metabolic process
B	0008144	molecular_function	obsolete drug binding
B	0009157	biological_process	deoxyribonucleoside monophosphate biosynthetic process
B	0009224	biological_process	CMP biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0019136	molecular_function	deoxynucleoside kinase activity
B	0032261	biological_process	purine nucleotide salvage
B	0042803	molecular_function	protein homodimerization activity
B	0043771	molecular_function	cytidine kinase activity
B	1901135	biological_process	carbohydrate derivative metabolic process
B	1901293	biological_process	nucleoside phosphate biosynthetic process
C	0000166	molecular_function	nucleotide binding
C	0004136	molecular_function	deoxyadenosine kinase activity
C	0004137	molecular_function	deoxycytidine kinase activity
C	0004138	molecular_function	deoxyguanosine kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0006139	biological_process	nucleobase-containing compound metabolic process
C	0006170	biological_process	dAMP biosynthetic process
C	0006220	biological_process	pyrimidine nucleotide metabolic process
C	0008144	molecular_function	obsolete drug binding
C	0009157	biological_process	deoxyribonucleoside monophosphate biosynthetic process
C	0009224	biological_process	CMP biosynthetic process
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0019136	molecular_function	deoxynucleoside kinase activity
C	0032261	biological_process	purine nucleotide salvage
C	0042803	molecular_function	protein homodimerization activity
C	0043771	molecular_function	cytidine kinase activity
C	1901135	biological_process	carbohydrate derivative metabolic process
C	1901293	biological_process	nucleoside phosphate biosynthetic process
D	0000166	molecular_function	nucleotide binding
D	0004136	molecular_function	deoxyadenosine kinase activity
D	0004137	molecular_function	deoxycytidine kinase activity
D	0004138	molecular_function	deoxyguanosine kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0006139	biological_process	nucleobase-containing compound metabolic process
D	0006170	biological_process	dAMP biosynthetic process
D	0006220	biological_process	pyrimidine nucleotide metabolic process
D	0008144	molecular_function	obsolete drug binding
D	0009157	biological_process	deoxyribonucleoside monophosphate biosynthetic process
D	0009224	biological_process	CMP biosynthetic process
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0019136	molecular_function	deoxynucleoside kinase activity
D	0032261	biological_process	purine nucleotide salvage
D	0042803	molecular_function	protein homodimerization activity
D	0043771	molecular_function	cytidine kinase activity
D	1901135	biological_process	carbohydrate derivative metabolic process
D	1901293	biological_process	nucleoside phosphate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue UDP A 301

Chain	Residue
A	ALA31
A	PHE242
A	LYS243
A	UMP302
A	MG303
A	ALA32
A	GLY33
A	LYS34
A	SER35
A	THR36
A	ARG188
A	ARG192
A	ASP241

site_id	AC2
Number of Residues	18
Details	binding site for residue UMP A 302

Chain	Residue
A	ILE30
A	ALA31
A	LYS34
A	GLU53
A	TRP58
A	LEU82
A	MET85
A	TYR86
A	PHE96
A	GLN97
A	ARG128
A	ASP133
A	PHE137
A	ARG192
A	ARG194
A	GLU197
A	UDP301
A	MG303

site_id	AC3
Number of Residues	4
Details	binding site for residue MG A 303

Chain	Residue
A	GLU127
A	ARG192
A	UDP301
A	UMP302

site_id	AC4
Number of Residues	16
Details	binding site for residue UDP B 301

Chain	Residue
B	ASN29
B	ALA31
B	ALA32
B	GLY33
B	LYS34
B	SER35
B	THR36
B	GLU127
B	ARG188
B	LEU191
B	ARG192
B	ASP241
B	PHE242
B	LYS243
B	UMP302
B	MG303

site_id	AC5
Number of Residues	17
Details	binding site for residue UMP B 302

Chain	Residue
B	ILE30
B	LYS34
B	GLU53
B	VAL55
B	TRP58
B	MET85
B	TYR86
B	PHE96
B	GLN97
B	ARG128
B	ASP133
B	PHE137
B	ARG192
B	ARG194
B	GLU197
B	UDP301
B	MG303

site_id	AC6
Number of Residues	6
Details	binding site for residue MG B 303

Chain	Residue
B	SER35
B	GLU53
B	GLU127
B	ARG194
B	UDP301
B	UMP302

site_id	AC7
Number of Residues	12
Details	binding site for residue UDP C 301

Chain	Residue
C	ALA31
C	ALA32
C	GLY33
C	LYS34
C	SER35
C	THR36
C	LEU191
C	ARG192
C	ASP241
C	PHE242
C	LYS243
C	UMP302

site_id	AC8
Number of Residues	18
Details	binding site for residue UMP C 302

Chain	Residue
C	ARG192
C	ARG194
C	GLU197
C	UDP301
C	MG303
C	ILE30
C	ALA31
C	LYS34
C	GLU53
C	TRP58
C	LEU82
C	MET85
C	TYR86
C	GLN97
C	GLU127
C	ARG128
C	ASP133
C	PHE137

site_id	AC9
Number of Residues	5
Details	binding site for residue MG C 303

Chain	Residue
C	SER35
C	GLU53
C	GLU127
C	ARG192
C	UMP302

site_id	AD1
Number of Residues	13
Details	binding site for residue UDP D 301

Chain	Residue
D	ALA31
D	ALA32
D	GLY33
D	LYS34
D	SER35
D	THR36
D	ARG188
D	ARG192
D	ASP241
D	PHE242
D	LYS243
D	UMP302
D	MG303

site_id	AD2
Number of Residues	18
Details	binding site for residue UMP D 302

Chain	Residue
D	ILE30
D	ALA31
D	LYS34
D	GLU53
D	TRP58
D	LEU82
D	MET85
D	TYR86
D	PHE96
D	GLN97
D	ARG128
D	ASP133
D	PHE137
D	ARG192
D	ARG194
D	GLU197
D	UDP301
D	MG303

site_id	AD3
Number of Residues	5
Details	binding site for residue MG D 303

Chain	Residue
D	GLU53
D	GLU127
D	ARG194
D	UDP301
D	UMP302

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	80
Details	Binding site: {}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)