5MLE

Crystal Structure of Human Dihydropyrimidinease-like 2 (DPYSL2A)/Collapsin Response Mediator Protein (CRMP2 13-516) Mutant Y479E/Y499E

Summary for 5MLE

Entry DOI	10.2210/pdb5mle/pdb
Descriptor	Dihydropyrimidinase-related protein 2, DI(HYDROXYETHYL)ETHER, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	crmp2, phospho-mutant, ovarian cancer, microtubule associated protein, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	111128.50
Authors	Sethi, R.,Zheng, Y.,Talon, R.,Velupillai, S.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Ahmed, A.A.,von Delft, F. (deposition date: 2016-12-06, release date: 2017-02-22, Last modification date: 2024-01-17)
Primary citation	Zheng, Y.,Sethi, R.,Mangala, L.S.,Taylor, C.,Goldsmith, J.,Wang, M.,Masuda, K.,Karaminejadranjbar, M.,Mannion, D.,Miranda, F.,Herrero-Gonzalez, S.,Hellner, K.,Chen, F.,Alsaadi, A.,Albukhari, A.,Fotso, D.C.,Yau, C.,Jiang, D.,Pradeep, S.,Rodriguez-Aguayo, C.,Lopez-Berestein, G.,Knapp, S.,Gray, N.S.,Campo, L.,Myers, K.A.,Dhar, S.,Ferguson, D.,Bast, R.C.,Sood, A.K.,von Delft, F.,Ahmed, A.A. Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation. Nat Commun, 9:476-476, 2018 Cited by PubMed: 29396402 DOI: 10.1038/s41467-017-02811-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.48 Å)

Structure validation