5MF4

Tubulin-Dictyostatin complex

Summary for 5MF4

• Entry DOI: 10.2210/pdb5mf4/pdb
• Related: 5LXS 5LXT
• Descriptor: Tubulin alpha-1B chain, (3~{Z},5~{E},7~{R},8~{S},10~{S},11~{Z},13~{S},14~{R},15~{S},17~{S},20~{R},21~{S},22~{S})-22-[(2~{S},3~{Z})-hexa-3,5-dien-2-yl]-7,13,15,17,21-pentamethyl-8,10,14,20-tetrakis(oxidanyl)-1-oxacyclodocosa-3,5,11-trien-2-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (13 entities in total)
• Functional Keywords: cell cycle, tubulin fold, cytoskeleton, microtubule
• Biological source: Rattus norvegicus (Norway Rat); More
• Total number of polymer chains: 6
• Total formula weight: 265926.91

Authors

Trigili, C.,Barasoain, I.,Sanchez-Murcia, P.A.,Bargsten, K.,Redondo-Horcajo, M.,Nogales, A.,Gardner, N.M.,Meyer, A.,Naylor, G.J.,Gomez-Rubio, E.,Gago, F.,Steinmetz, M.O.,Paterson, I.,Prota, A.E.,Diaz, J.F. (deposition date: 2016-11-17, release date: 2017-09-20, Last modification date: 2024-01-17)

• Primary citation: Trigili, C.,Barasoain, I.,Sanchez-Murcia, P.A.,Bargsten, K.,Redondo-Horcajo, M.,Nogales, A.,Gardner, N.M.,Meyer, A.,Naylor, G.J.,Gomez-Rubio, E.,Gago, F.,Steinmetz, M.O.,Paterson, I.,Prota, A.E.,Diaz, J.F.; Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells.; ACS Omega, 1:1192-1204, 2016; PubMed: 30023505; DOI: 10.1021/acsomega.6b00317

Experimental method

X-RAY DIFFRACTION (2.3 Å)