5MAR
Structure of human SIRT2 in complex with 1,2,4-Oxadiazole inhibitor and ADP ribose.
Summary for 5MAR
| Entry DOI | 10.2210/pdb5mar/pdb |
| Descriptor | NAD-dependent protein deacetylase sirtuin-2, ZINC ION, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ... (9 entities in total) |
| Functional Keywords | sirtuin, nad-dependent protein deacylase, inhibitor complex, hydrolase |
| Biological source | Homo sapiens (Human) |
| Cellular location | Nucleus. Isoform 1: Cytoplasm . Isoform 2: Cytoplasm . Isoform 5: Cytoplasm : Q8IXJ6 |
| Total number of polymer chains | 2 |
| Total formula weight | 71700.89 |
| Authors | Moniot, S.,Steegborn, C. (deposition date: 2016-11-04, release date: 2017-03-15, Last modification date: 2024-01-17) |
| Primary citation | Moniot, S.,Forgione, M.,Lucidi, A.,Hailu, G.S.,Nebbioso, A.,Carafa, V.,Baratta, F.,Altucci, L.,Giacche, N.,Passeri, D.,Pellicciari, R.,Mai, A.,Steegborn, C.,Rotili, D. Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure-Activity Relationship, X-ray Crystal Structure, and Anticancer Activity. J. Med. Chem., 60:2344-2360, 2017 Cited by PubMed: 28240897DOI: 10.1021/acs.jmedchem.6b01609 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.89 Å) |
Structure validation
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