5MAR
Structure of human SIRT2 in complex with 1,2,4-Oxadiazole inhibitor and ADP ribose.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | NAD-dependent protein deacetylase sirtuin-2 | polymer | 303 | 34359.7 | 2 | UniProt (Q8IXJ6) Pfam (PF02146) | Homo sapiens (Human) | Regulatory protein SIR2 homolog 2,SIR2-like protein 2 |
| 2 | C, O (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, P (A, B) | [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | non-polymer | 559.3 | 2 | Chemie (AR6) | |||
| 4 | E, Q (A, B) | 3-[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]propan-1-ol | non-polymer | 238.7 | 2 | Chemie (7KE) | |||
| 5 | F, G (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 6 | H, I, J, K, L... (A, B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 9 | Chemie (DMS) | |||
| 7 | M, N, W, X (A, B) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 8 | R (B) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 9 | Y, Z (A, B) | water | water | 18.0 | 473 | Chemie (HOH) |
Sequence modifications
A, B: 56 - 356 (UniProt: Q8IXJ6)
| PDB | External Database | Details |
|---|---|---|
| His 54 | - | expression tag |
| Met 55 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 68719.4 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 2981.5 | |
| All* | Total formula weight | 71700.9 |
