5M8D

Tubulin MTD265-R1 complex

Summary for 5M8D

Entry DOI	10.2210/pdb5m8d/pdb
Related	4O2B 5M7E 5M7G
Descriptor	Tubulin alpha-1B chain, GUANOSINE-5'-DIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (13 entities in total)
Functional Keywords	cell cycle, tubulin fold, cytoskeleton, microtubule
Biological source	Rattus norvegicus (Rat) More
Cellular location	Cytoplasm, cytoskeleton: P81947 Q6B856 Golgi apparatus : P63043
Total number of polymer chains	6
Total formula weight	265072.93
Authors	Bohnacker, T.,Prota, A.E.,Steinmetz, M.O.,Wymann, M.P. (deposition date: 2016-10-28, release date: 2017-03-22, Last modification date: 2024-01-17)
Primary citation	Bohnacker, T.,Prota, A.E.,Beaufils, F.,Burke, J.E.,Melone, A.,Inglis, A.J.,Rageot, D.,Sele, A.M.,Cmiljanovic, V.,Cmiljanovic, N.,Bargsten, K.,Aher, A.,Akhmanova, A.,Diaz, J.F.,Fabbro, D.,Zvelebil, M.,Williams, R.L.,Steinmetz, M.O.,Wymann, M.P. Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention. Nat Commun, 8:14683-14683, 2017 Cited by PubMed: 28276440 DOI: 10.1038/ncomms14683 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation