Tubulin-MTD147 complex

Summary for 5M7G

Related4O2B 5M7E
DescriptorTubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ... (13 entities in total)
Functional Keywordscell cycle, tubulin fold, cytoskeleton, microtubule
Biological sourceRattus norvegicus (Norway Rat)
Cellular locationCytoplasm, cytoskeleton P81947 Q6B856
Golgi apparatus  P63043
Total number of polymer chains6
Total molecular weight265589.44
Bohnacker, T.,Prota, A.E.,Steinmetz, M.O.,Wymann, M.P. (deposition date: 2016-10-27, release date: 2017-02-22, Last modification date: 2017-09-13)
Primary citation
Bohnacker, T.,Prota, A.E.,Beaufils, F.,Burke, J.E.,Melone, A.,Inglis, A.J.,Rageot, D.,Sele, A.M.,Cmiljanovic, V.,Cmiljanovic, N.,Bargsten, K.,Aher, A.,Akhmanova, A.,Diaz, J.F.,Fabbro, D.,Zvelebil, M.,Williams, R.L.,Steinmetz, M.O.,Wymann, M.P.
Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.
Nat Commun, 8:14683-14683, 2017
PubMed: 28276440 (PDB entries with the same primary citation)
DOI: 10.1038/ncomms14683
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.21840.0%1.2%9.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-09-16