5M7G
Tubulin-MTD147 complex
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000226 | biological_process | microtubule cytoskeleton organization |
A | 0000278 | biological_process | mitotic cell cycle |
A | 0003924 | molecular_function | GTPase activity |
A | 0005200 | molecular_function | structural constituent of cytoskeleton |
A | 0005525 | molecular_function | GTP binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0005856 | cellular_component | cytoskeleton |
A | 0005874 | cellular_component | microtubule |
A | 0007017 | biological_process | microtubule-based process |
A | 0015630 | cellular_component | microtubule cytoskeleton |
A | 0016787 | molecular_function | hydrolase activity |
A | 0046872 | molecular_function | metal ion binding |
B | 0000226 | biological_process | microtubule cytoskeleton organization |
B | 0000278 | biological_process | mitotic cell cycle |
B | 0003924 | molecular_function | GTPase activity |
B | 0005200 | molecular_function | structural constituent of cytoskeleton |
B | 0005525 | molecular_function | GTP binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0005856 | cellular_component | cytoskeleton |
B | 0005874 | cellular_component | microtubule |
B | 0007017 | biological_process | microtubule-based process |
B | 0007399 | biological_process | nervous system development |
B | 0015630 | cellular_component | microtubule cytoskeleton |
B | 0046872 | molecular_function | metal ion binding |
B | 0046982 | molecular_function | protein heterodimerization activity |
B | 1902669 | biological_process | positive regulation of axon guidance |
C | 0000226 | biological_process | microtubule cytoskeleton organization |
C | 0000278 | biological_process | mitotic cell cycle |
C | 0003924 | molecular_function | GTPase activity |
C | 0005200 | molecular_function | structural constituent of cytoskeleton |
C | 0005525 | molecular_function | GTP binding |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0005856 | cellular_component | cytoskeleton |
C | 0005874 | cellular_component | microtubule |
C | 0007017 | biological_process | microtubule-based process |
C | 0015630 | cellular_component | microtubule cytoskeleton |
C | 0016787 | molecular_function | hydrolase activity |
C | 0046872 | molecular_function | metal ion binding |
D | 0000226 | biological_process | microtubule cytoskeleton organization |
D | 0000278 | biological_process | mitotic cell cycle |
D | 0003924 | molecular_function | GTPase activity |
D | 0005200 | molecular_function | structural constituent of cytoskeleton |
D | 0005525 | molecular_function | GTP binding |
D | 0005737 | cellular_component | cytoplasm |
D | 0005856 | cellular_component | cytoskeleton |
D | 0005874 | cellular_component | microtubule |
D | 0007017 | biological_process | microtubule-based process |
D | 0007399 | biological_process | nervous system development |
D | 0015630 | cellular_component | microtubule cytoskeleton |
D | 0046872 | molecular_function | metal ion binding |
D | 0046982 | molecular_function | protein heterodimerization activity |
D | 1902669 | biological_process | positive regulation of axon guidance |
E | 0031110 | biological_process | regulation of microtubule polymerization or depolymerization |
F | 0036211 | biological_process | protein modification process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 30 |
Details | binding site for residue GTP A 501 |
Chain | Residue |
A | GLY10 |
A | GLY143 |
A | GLY144 |
A | THR145 |
A | GLY146 |
A | VAL177 |
A | SER178 |
A | THR179 |
A | GLU183 |
A | ASN206 |
A | TYR224 |
A | GLN11 |
A | ASN228 |
A | ILE231 |
A | MG502 |
A | HOH606 |
A | HOH608 |
A | HOH618 |
A | HOH627 |
A | HOH637 |
A | HOH639 |
A | HOH660 |
A | ALA12 |
B | LYS254 |
A | GLN15 |
A | ASP98 |
A | ALA99 |
A | ALA100 |
A | ASN101 |
A | SER140 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue MG A 502 |
Chain | Residue |
A | GTP501 |
A | HOH606 |
A | HOH618 |
A | HOH627 |
A | HOH660 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue CA A 503 |
Chain | Residue |
A | ASP39 |
A | THR41 |
A | GLY44 |
A | GLU55 |
A | HOH622 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue CA A 504 |
Chain | Residue |
A | HOH643 |
A | HOH651 |
A | HOH662 |
E | ASP44 |
site_id | AC5 |
Number of Residues | 7 |
Details | binding site for residue GOL A 505 |
Chain | Residue |
A | ASN216 |
A | PRO274 |
A | VAL275 |
A | ILE276 |
A | ALA294 |
A | ASN300 |
A | HOH666 |
site_id | AC6 |
Number of Residues | 18 |
Details | binding site for residue FB7 B 501 |
Chain | Residue |
A | ASN101 |
A | VAL181 |
B | TYR202 |
B | VAL238 |
B | CYS241 |
B | LEU248 |
B | LYS254 |
B | LEU255 |
B | ASN258 |
B | MET259 |
B | VAL315 |
B | ILE318 |
B | ASN349 |
B | ASN350 |
B | LYS352 |
B | ALA354 |
B | ILE378 |
B | HOH655 |
site_id | AC7 |
Number of Residues | 22 |
Details | binding site for residue GDP B 502 |
Chain | Residue |
B | GLY10 |
B | GLN11 |
B | CYS12 |
B | GLN15 |
B | SER140 |
B | GLY143 |
B | GLY144 |
B | THR145 |
B | GLY146 |
B | VAL177 |
B | ASP179 |
B | GLU183 |
B | ASN206 |
B | TYR224 |
B | ASN228 |
B | MG503 |
B | HOH608 |
B | HOH610 |
B | HOH613 |
B | HOH620 |
B | HOH625 |
B | HOH631 |
site_id | AC8 |
Number of Residues | 6 |
Details | binding site for residue MG B 503 |
Chain | Residue |
B | GLN11 |
B | GDP502 |
B | HOH605 |
B | HOH635 |
B | HOH669 |
C | HOH607 |
site_id | AC9 |
Number of Residues | 4 |
Details | binding site for residue CA B 504 |
Chain | Residue |
C | HOH610 |
C | HOH741 |
B | GLU113 |
B | HOH652 |
site_id | AD1 |
Number of Residues | 7 |
Details | binding site for residue MES B 505 |
Chain | Residue |
B | ARG158 |
B | PRO162 |
B | ASP163 |
B | ARG164 |
B | ASN197 |
B | ASP199 |
B | ARG253 |
site_id | AD2 |
Number of Residues | 29 |
Details | binding site for residue GTP C 501 |
Chain | Residue |
C | GLY10 |
C | GLN11 |
C | ALA12 |
C | GLN15 |
C | ASP98 |
C | ALA99 |
C | ASN101 |
C | SER140 |
C | GLY143 |
C | GLY144 |
C | THR145 |
C | GLY146 |
C | VAL177 |
C | THR179 |
C | GLU183 |
C | ASN206 |
C | TYR224 |
C | ASN228 |
C | ILE231 |
C | MG502 |
C | HOH620 |
C | HOH637 |
C | HOH638 |
C | HOH640 |
C | HOH646 |
C | HOH663 |
C | HOH675 |
C | HOH700 |
D | LYS254 |
site_id | AD3 |
Number of Residues | 5 |
Details | binding site for residue MG C 502 |
Chain | Residue |
C | GTP501 |
C | HOH637 |
C | HOH638 |
C | HOH646 |
C | HOH700 |
site_id | AD4 |
Number of Residues | 5 |
Details | binding site for residue CA C 503 |
Chain | Residue |
C | ASP39 |
C | THR41 |
C | GLY44 |
C | GLU55 |
C | HOH605 |
site_id | AD5 |
Number of Residues | 4 |
Details | binding site for residue CA C 504 |
Chain | Residue |
B | HOH632 |
B | HOH640 |
C | HOH763 |
C | HOH767 |
site_id | AD6 |
Number of Residues | 17 |
Details | binding site for residue FB7 D 500 |
Chain | Residue |
C | ASN101 |
C | THR179 |
D | TYR202 |
D | VAL238 |
D | CYS241 |
D | LEU255 |
D | ASN258 |
D | MET259 |
D | VAL315 |
D | ALA316 |
D | ILE318 |
D | ASN349 |
D | ASN350 |
D | LYS352 |
D | ALA354 |
D | ILE378 |
D | HOH618 |
site_id | AD7 |
Number of Residues | 17 |
Details | binding site for residue GDP D 501 |
Chain | Residue |
D | GLY10 |
D | GLN11 |
D | CYS12 |
D | GLN15 |
D | SER140 |
D | GLY143 |
D | GLY144 |
D | THR145 |
D | GLY146 |
D | VAL177 |
D | GLU183 |
D | ASN206 |
D | TYR224 |
D | ASN228 |
D | MG502 |
D | HOH601 |
D | HOH616 |
site_id | AD8 |
Number of Residues | 6 |
Details | binding site for residue MG D 502 |
Chain | Residue |
D | GLN11 |
D | ASP179 |
D | GDP501 |
D | HOH601 |
D | HOH616 |
D | HOH642 |
site_id | AD9 |
Number of Residues | 4 |
Details | binding site for residue GOL F 401 |
Chain | Residue |
F | TYR211 |
F | MET296 |
F | LEU378 |
F | HIS379 |
site_id | AE1 |
Number of Residues | 4 |
Details | binding site for residue MG F 402 |
Chain | Residue |
F | LYS74 |
F | GLU331 |
F | ASN333 |
F | ACP403 |
site_id | AE2 |
Number of Residues | 19 |
Details | binding site for residue ACP F 403 |
Chain | Residue |
F | LYS74 |
F | LYS150 |
F | GLN183 |
F | LYS184 |
F | TYR185 |
F | LEU186 |
F | LYS198 |
F | ASP200 |
F | ARG202 |
F | ARG222 |
F | LEU240 |
F | THR241 |
F | ASN242 |
F | ASP318 |
F | ILE330 |
F | GLU331 |
F | ASN333 |
F | MG402 |
F | HOH501 |
Functional Information from PROSITE/UniProt
site_id | PS00227 |
Number of Residues | 7 |
Details | TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG |
Chain | Residue | Details |
B | GLY142-GLY148 | |
A | GLY142-GLY148 |
site_id | PS00228 |
Number of Residues | 4 |
Details | TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI |
Chain | Residue | Details |
B | MET1-ILE4 |
site_id | PS00563 |
Number of Residues | 10 |
Details | STATHMIN_1 Stathmin family signature 1. PRRRDpSLEE |
Chain | Residue | Details |
E | PRO40-GLU49 |
site_id | PS01041 |
Number of Residues | 10 |
Details | STATHMIN_2 Stathmin family signature 2. AEKREHEREV |
Chain | Residue | Details |
E | ALA73-VAL82 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903 |
Chain | Residue | Details |
E | SER46 | |
D | GLY144 | |
D | THR145 | |
D | GLY146 | |
D | ASN206 | |
D | ASN228 | |
B | SER140 | |
B | GLY144 | |
B | THR145 | |
B | GLY146 | |
B | ASN206 | |
B | ASN228 | |
D | GLN11 | |
D | SER140 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P68363 |
Chain | Residue | Details |
B | GLU71 | |
C | GLU71 | |
C | SER140 | |
C | GLY144 | |
C | THR145 | |
C | THR179 | |
C | ASN206 | |
C | ASN228 | |
D | GLU71 | |
A | SER140 | |
A | GLY144 | |
A | THR145 | |
A | THR179 | |
A | ASN206 | |
A | ASN228 | |
C | GLN11 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P99024 |
Chain | Residue | Details |
B | SER40 | |
D | SER40 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q3KRE8 |
Chain | Residue | Details |
B | THR57 | |
D | THR57 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P99024 |
Chain | Residue | Details |
B | LYS60 | |
D | LYS60 | |
C | SER48 | |
C | SER232 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine; by CDK1 => ECO:0000250|UniProtKB:Q9BVA1 |
Chain | Residue | Details |
B | SER174 | |
D | SER174 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P07437 |
Chain | Residue | Details |
B | THR287 | |
B | THR292 | |
D | THR287 | |
D | THR292 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:P07437 |
Chain | Residue | Details |
B | ARG320 | |
D | ARG320 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | MOD_RES: 5-glutamyl polyglutamate => ECO:0000250|UniProtKB:Q2T9S0 |
Chain | Residue | Details |
B | GLU448 | |
D | GLU448 |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P07437 |
Chain | Residue | Details |
B | LYS60 | |
D | LYS60 |
site_id | SWS_FT_FI11 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P07437 |
Chain | Residue | Details |
A | TYR451 | |
B | LYS326 | |
D | LYS326 |
site_id | SWS_FT_FI12 |
Number of Residues | 6 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P68363 |
Chain | Residue | Details |
A | LYS326 | |
A | LYS370 | |
C | LYS326 | |
C | LYS370 |