5M7G
Tubulin-MTD147 complex
Summary for 5M7G
Entry DOI | 10.2210/pdb5m7g/pdb |
Related | 4O2B 5M7E |
Descriptor | Tubulin alpha-1B chain, GUANOSINE-5'-DIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (13 entities in total) |
Functional Keywords | cell cycle, tubulin fold, cytoskeleton, microtubule |
Biological source | Rattus norvegicus (Norway Rat) More |
Cellular location | Cytoplasm, cytoskeleton: P81947 Q6B856 Golgi apparatus : P63043 |
Total number of polymer chains | 6 |
Total formula weight | 265589.44 |
Authors | Bohnacker, T.,Prota, A.E.,Steinmetz, M.O.,Wymann, M.P. (deposition date: 2016-10-27, release date: 2017-02-22, Last modification date: 2024-01-17) |
Primary citation | Bohnacker, T.,Prota, A.E.,Beaufils, F.,Burke, J.E.,Melone, A.,Inglis, A.J.,Rageot, D.,Sele, A.M.,Cmiljanovic, V.,Cmiljanovic, N.,Bargsten, K.,Aher, A.,Akhmanova, A.,Diaz, J.F.,Fabbro, D.,Zvelebil, M.,Williams, R.L.,Steinmetz, M.O.,Wymann, M.P. Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention. Nat Commun, 8:14683-14683, 2017 Cited by PubMed: 28276440DOI: 10.1038/ncomms14683 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.248 Å) |
Structure validation
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