5M0C
Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with the Fasudil-fragment isoquinoline-5-sulfonamide
Summary for 5M0C
Entry DOI | 10.2210/pdb5m0c/pdb |
Related | 5LCP 5LCQ 5LCR 5LCT 5LCU 5M0B |
Descriptor | cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, isoquinoline-5-sulfonamide, ... (6 entities in total) |
Functional Keywords | pka, kinase, fasudil-derivative, inhibition, cocrystal, 3x-phosphorylated, ligand 01, transferase |
Biological source | Cricetulus griseus (Chinese hamster) More |
Total number of polymer chains | 2 |
Total formula weight | 43744.72 |
Authors | Wienen-Schmidt, B.,Heine, A.,Klebe, G. (deposition date: 2016-10-04, release date: 2018-06-06, Last modification date: 2024-01-17) |
Primary citation | Wienen-Schmidt, B.,Jonker, H.,Gerber, H.-D.,Saxena, K.,Kudlinzki, D.,Sreeramulu, S.,Heine, A.,Schwalbe, H.,Klebe, G. Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with different Fasudil-derivatives To be Published, |
Experimental method | X-RAY DIFFRACTION (1.734 Å) |
Structure validation
Download full validation report