5M0B

Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with a short-chained N-(2-aminoethyl)isoquinoline-5-sulfonamide) Fasudil-derivative (Ligand 03)

Summary for 5M0B

• Entry DOI: 10.2210/pdb5m0b/pdb
• Related: 5LCP 5LCQ 5LCR 5LCT 5LCU
• Descriptor: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, N-(2-AMINOETHYL)ISOQUINOLINE-5-SULFONAMIDE, ... (6 entities in total)
• Functional Keywords: pka, kinase, fasudil-derivative, inhibition, cocrystal, 3x-phosphorylated, transferase, ligand 03
• Biological source: Cricetulus griseus (Chinese hamster); More
• Total number of polymer chains: 2
• Total formula weight: 43773.74

Authors

Wienen-Schmidt, B.,Heine, A.,Klebe, G. (deposition date: 2016-10-04, release date: 2018-06-06, Last modification date: 2024-10-16)

• Primary citation: Wienen-Schmidt, B.,Jonker, H.R.A.,Gerber, H.-D.,Saxena, K.,Kudlinzki, D.,Sreeramulu, S.,Heine, A.,Schwalbe, H.,Klebe, G.; Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with different Fasudil-derivatives; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.506 Å)