5M0B

Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with a short-chained N-(2-aminoethyl)isoquinoline-5-sulfonamide) Fasudil-derivative (Ligand 03)

5M0B の概要

• エントリーDOI: 10.2210/pdb5m0b/pdb
• 関連するPDBエントリー: 5LCP 5LCQ 5LCR 5LCT 5LCU
• 分子名称: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, N-(2-AMINOETHYL)ISOQUINOLINE-5-SULFONAMIDE, ... (6 entities in total)
• 機能のキーワード: pka, kinase, fasudil-derivative, inhibition, cocrystal, 3x-phosphorylated, transferase, ligand 03
• 由来する生物種: Cricetulus griseus (Chinese hamster); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43773.74

構造登録者

Wienen-Schmidt, B.,Heine, A.,Klebe, G. (登録日: 2016-10-04, 公開日: 2018-06-06, 最終更新日: 2024-10-16)

• 主引用文献: Wienen-Schmidt, B.,Jonker, H.R.A.,Gerber, H.-D.,Saxena, K.,Kudlinzki, D.,Sreeramulu, S.,Heine, A.,Schwalbe, H.,Klebe, G.; Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with different Fasudil-derivatives; To Be Published,

実験手法

X-RAY DIFFRACTION (1.506 Å)