5LYO

Crystal structure of the zymogen matriptase catalytic domain

Summary for 5LYO

Entry DOI	10.2210/pdb5lyo/pdb
Descriptor	Suppressor of tumorigenicity 14 protein, SULFATE ION (3 entities in total)
Functional Keywords	serine protease, enzyme inhibitor, zymogen, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	89415.53
Authors	Hong, Z.,Jensen, J.K. (deposition date: 2016-09-28, release date: 2017-10-25, Last modification date: 2024-01-17)
Primary citation	Tamberg, T.,Hong, Z.,De Schepper, D.,Skovbjerg, S.,Dupont, D.M.,Vitved, L.,Schar, C.R.,Skjoedt, K.,Vogel, L.K.,Jensen, J.K. Blocking the proteolytic activity of zymogen matriptase with antibody-based inhibitors. J.Biol.Chem., 294:314-326, 2019 Cited by PubMed: 30409910 DOI: 10.1074/jbc.RA118.004126 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.498 Å)

Structure validation