5LYO

Crystal structure of the zymogen matriptase catalytic domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Suppressor of tumorigenicity 14 protein	polymer	265	29132.7	3	UniProt (Q9Y5Y6) Pfam (PF00089)	Homo sapiens (Human)	Matriptase,Membrane-type serine protease 1,MT-SP1,Prostamin,Serine protease 14,Serine protease TADG-15,Tumor-associated differentially-expressed gene 15 protein
2	D, E, F, G, H... (A, B, C)	SULFATE ION	non-polymer		96.1	21	Chemie (SO4)
3	AA, Y, Z (C, A, B)	water	water		18.0	167	Chemie (HOH)

Sequence modifications

A, B, C: 604 - 855 (UniProt: Q9Y5Y6)

PDB	External Database	Details
Ser 591	-	expression tag
Met 592	-	expression tag
Asn 593	-	expression tag
Ser 594	-	expression tag
His 595	-	expression tag
His 596	-	expression tag
His 597	-	expression tag
His 598	-	expression tag
His 599	-	expression tag
His 600	-	expression tag
Gly 601	-	expression tag
Thr 602	-	expression tag
Ala 603	-	expression tag
Ala 614	Arg 614	engineered mutation
Gln 772	Asn 772	engineered mutation
Ala 805	Ser 805	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	87398.2
Non-Polymers*	Number of molecules	21
	Total formula weight	2017.3
All*	Total formula weight	89415.5

*Water molecules are not included.