5LYO

Crystal structure of the zymogen matriptase catalytic domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
B	0004252	molecular_function	serine-type endopeptidase activity
B	0006508	biological_process	proteolysis
C	0004252	molecular_function	serine-type endopeptidase activity
C	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue SO4 A 901

Chain	Residue
A	HIS656
A	ALA805
A	TRP826
A	GLY827

---

site_id	AC2
Number of Residues	6
Details	binding site for residue SO4 A 902

Chain	Residue
A	ARG684
A	HIS633
A	LEU635
A	GLY636
A	GLN637
A	GLY638

---

site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 A 903

Chain	Residue
A	ASP734
A	HIS737
A	PHE819

---

site_id	AC4
Number of Residues	6
Details	binding site for residue SO4 A 904

Chain	Residue
A	ARG611
A	GLN612
A	ARG833
B	GLN832
B	ASN834
B	LYS835

---

site_id	AC5
Number of Residues	3
Details	binding site for residue SO4 A 905

Chain	Residue
A	HIS752
A	THR758
C	GLN772

---

site_id	AC6
Number of Residues	2
Details	binding site for residue SO4 A 906

Chain	Residue
A	GLU691
A	ARG692

---

site_id	AC7
Number of Residues	2
Details	binding site for residue SO4 A 907

Chain	Residue
A	VAL770
A	HOH1002

---

site_id	AC8
Number of Residues	4
Details	binding site for residue SO4 B 901

Chain	Residue
B	HIS656
B	ALA805
B	TRP826
B	GLY827

---

site_id	AC9
Number of Residues	5
Details	binding site for residue SO4 B 902

Chain	Residue
B	HIS633
B	GLY636
B	GLN637
B	GLY638
B	ARG684

---

site_id	AD1
Number of Residues	3
Details	binding site for residue SO4 B 903

Chain	Residue
B	GLN690
B	GLU691
B	ARG692

---

site_id	AD2
Number of Residues	4
Details	binding site for residue SO4 B 904

Chain	Residue
B	ARG833
B	ASN834
B	HOH1004
B	HOH1024

---

site_id	AD3
Number of Residues	4
Details	binding site for residue SO4 B 905

Chain	Residue
A	GLN772
B	HIS752
B	THR758
B	HOH1013

---

site_id	AD4
Number of Residues	4
Details	binding site for residue SO4 C 901

Chain	Residue
C	HIS656
C	ALA805
C	TRP826
C	GLY827

---

site_id	AD5
Number of Residues	5
Details	binding site for residue SO4 C 902

Chain	Residue
A	PHE706
C	PRO648
C	ALA721
C	GLU722
C	TYR723

---

site_id	AD6
Number of Residues	3
Details	binding site for residue SO4 C 903

Chain	Residue
C	PRO733
C	ASP734
C	HIS737

---

site_id	AD7
Number of Residues	4
Details	binding site for residue SO4 C 904

Chain	Residue
B	GLN772
C	HIS752
C	THR758
C	HOH1008

---

site_id	AD8
Number of Residues	8
Details	binding site for residue SO4 C 905

Chain	Residue
A	ARG833
A	HOH1006
A	HOH1024
A	HOH1029
A	HOH1047
A	HOH1054
B	ARG833
C	ARG833

---

site_id	AD9
Number of Residues	3
Details	binding site for residue SO4 C 906

Chain	Residue
C	THR610
C	ARG833
C	ASN834

---

site_id	AE1
Number of Residues	4
Details	binding site for residue SO4 C 907

Chain	Residue
C	ARG607
C	PHE609
C	GLU625
C	TRP626

---

site_id	AE2
Number of Residues	5
Details	binding site for residue SO4 C 908

Chain	Residue
C	VAL689
C	GLN690
C	GLU691
C	ARG692
C	GLU722

---

site_id	AE3
Number of Residues	1
Details	binding site for residue SO4 C 909

Chain	Residue
C	SER725

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC

Chain	Residue	Details
A	VAL652-CYS657

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	478
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	Active site: {"description":"Charge relay system"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---