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5LXM

Crystal structure of Aurora-A bound to a hydrocarbon-stapled proteomimetic of TPX2

Summary for 5LXM
Entry DOI10.2210/pdb5lxm/pdb
DescriptorAurora kinase A, MAGNESIUM ION, AMMONIA, ... (12 entities in total)
Functional Keywordsprotein kinase, proteomimetic, stapled helix peptide, mitosis, transferase
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains2
Total formula weight38589.29
Authors
McIntyre, P.J.,Bayliss, R. (deposition date: 2016-09-22, release date: 2016-11-02, Last modification date: 2024-02-07)
Primary citationRennie, Y.K.,McIntyre, P.J.,Akindele, T.,Bayliss, R.,Jamieson, A.G.
A TPX2 Proteomimetic Has Enhanced Affinity for Aurora-A Due to Hydrocarbon Stapling of a Helix.
ACS Chem. Biol., 11:3383-3390, 2016
Cited by
PubMed: 27775325
DOI: 10.1021/acschembio.6b00727
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.08 Å)
Structure validation

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