5LSU
Structure of the Epigenetic Oncogene MMSET and inhibition by N-Alkyl Sinefungin Derivatives
Summary for 5LSU
Entry DOI | 10.2210/pdb5lsu/pdb |
Descriptor | Histone-lysine N-methyltransferase NSD2, ZINC ION, S-ADENOSYLMETHIONINE, ... (4 entities in total) |
Functional Keywords | lysine methyltransferase mmset set domain, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus . Isoform 4: Cytoplasm: O96028 |
Total number of polymer chains | 2 |
Total formula weight | 58763.03 |
Authors | Tisi, D.,Pathuri, P.,Heightman, T. (deposition date: 2016-09-05, release date: 2016-10-05, Last modification date: 2024-01-17) |
Primary citation | Tisi, D.,Chiarparin, E.,Tamanini, E.,Pathuri, P.,Coyle, J.E.,Hold, A.,Holding, F.P.,Amin, N.,Martin, A.C.,Rich, S.J.,Berdini, V.,Yon, J.,Acklam, P.,Burke, R.,Drouin, L.,Harmer, J.E.,Jeganathan, F.,van Montfort, R.L.,Newbatt, Y.,Tortorici, M.,Westlake, M.,Wood, A.,Hoelder, S.,Heightman, T.D. Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives. ACS Chem. Biol., 11:3093-3105, 2016 Cited by PubMed: 27571355DOI: 10.1021/acschembio.6b00308 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.14 Å) |
Structure validation
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