5LSU
Structure of the Epigenetic Oncogene MMSET and inhibition by N-Alkyl Sinefungin Derivatives
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Histone-lysine N-methyltransferase NSD2 | polymer | 252 | 28786.8 | 2 | UniProt (O96028) Pfam (PF17907) Pfam (PF00856) In PDB | Homo sapiens (Human) | Multiple myeloma SET domain-containing protein,MMSET,Nuclear SET domain-containing protein 2,NSD2,Protein trithorax-5,Wolf-Hirschhorn syndrome candidate 1 protein,WHSC1 |
2 | A, B | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
3 | A, B | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 2 | Chemie (SAM) | |||
4 | water | water | 18.0 | 528 | Chemie (HOH) |
Sequence modifications
A, B: 973 - 1203 (UniProt: O96028)
PDB | External Database | Details |
---|---|---|
Met 952 | - | initiating methionine |
Gly 953 | - | expression tag |
Ser 954 | - | expression tag |
Ser 955 | - | expression tag |
His 956 | - | expression tag |
His 957 | - | expression tag |
His 958 | - | expression tag |
His 959 | - | expression tag |
His 960 | - | expression tag |
His 961 | - | expression tag |
Ser 962 | - | expression tag |
Ser 963 | - | expression tag |
Gly 964 | - | expression tag |
Leu 965 | - | expression tag |
Val 966 | - | expression tag |
Pro 967 | - | expression tag |
Arg 968 | - | expression tag |
Gly 969 | - | expression tag |
Ser 970 | - | expression tag |
His 971 | - | expression tag |
Met 972 | - | expression tag |
Leu 975 | Gln 975 | engineered mutation |
Leu 978 | Ala 978 | engineered mutation |
Leu 1071 | Asp 1071 | engineered mutation |
Gln 1072 | Gly 1072 | engineered mutation |
Arg 1073 | Lys 1073 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 57573.7 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 1189.3 | |
All* | Total formula weight | 58763.0 |