5LPP

tRNA guanine Transglycosylase (TGT) in co-crystallized complex (space group C2) with 6-amino-4-(2-((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)ethyl)-2-(methylamino)-1H-imidazo[4,5-g]quinazolin-8(7H)-one

Summary for 5LPP

• Entry DOI: 10.2210/pdb5lpp/pdb
• Related: 1P0D 4KWO 4LEQ 4PUK 5I00 5I02 5I06 5LPO
• Descriptor: Queuine tRNA-ribosyltransferase, ZINC ION, 4-[2-[(3~{a}~{R},4~{R},6~{R},6~{a}~{R})-4-methoxy-2,2-dimethyl-3~{a},4,6,6~{a}-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]ethyl]-6-azanyl-2-(methylamino)-1,7-dihydroimidazo[4,5-g]quinazolin-8-one, ... (4 entities in total)
• Functional Keywords: carbohydrate-based inhibitors, homodimer, shigellosis, transferase, transferase inhibitor
• Biological source: Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
• Total number of polymer chains: 1
• Total formula weight: 43421.57

Authors

Ehrmann, F.R.,Heine, A.,Klebe, G. (deposition date: 2016-08-14, release date: 2017-08-30, Last modification date: 2024-01-10)

• Primary citation: Ehrmann, F.R.,Botzanowski, T.,Pfaffender, T.,Heine, A.,Diederich, F.,Sanglier-Cianferani, S.,Klebe, G.; Carbohydrate-based Inhibitors targeting the Ribose-34 pocket of Z.mobilis TGT and changing the oligomeric state of the homodimer; To be published,

Experimental method

X-RAY DIFFRACTION (1.99 Å)