5LJ0

Crystal structure of human ATAD2 bromodomain in complex with 8-(((3R,4R,5S)-3-((4,4-difluorocyclohexyl)methoxy)-5-methoxypiperidin-4-yl)amino)-3-methyl-5-(5-methylpyridin-3-yl)-1,7-naphthyridin-2(1H)-one

Summary for 5LJ0

• Entry DOI: 10.2210/pdb5lj0/pdb
• Descriptor: ATPase family AAA domain-containing protein 2, 1,2-ETHANEDIOL, 8-(((3R,4R,5S)-3-((4,4-difluorocyclohexyl)methoxy)-5-methoxypiperidin-4-yl)amino)-3-methyl-5-(5-methylpyridin-3-yl)-1,7-naphthyridin-2(1H)-one, ... (5 entities in total)
• Functional Keywords: inhibitor, atad2, bromodomain, epigenetics, atpase family aaa domain-containing protein 2, transcription
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : Q6PL18
• Total number of polymer chains: 1
• Total formula weight: 16325.45

Authors

Chung, C. (deposition date: 2016-07-17, release date: 2016-08-31, Last modification date: 2016-09-14)

• Primary citation: Bamborough, P.,Chung, C.W.,Demont, E.H.,Furze, R.C.,Bannister, A.J.,Che, K.H.,Diallo, H.,Douault, C.,Grandi, P.,Kouzarides, T.,Michon, A.M.,Mitchell, D.J.,Prinjha, R.K.,Rau, C.,Robson, S.,Sheppard, R.J.,Upton, R.,Watson, R.J.; A Chemical Probe for the ATAD2 Bromodomain.; Angew.Chem.Int.Ed.Engl., 55:11382-11386, 2016; PubMed: 27530368; DOI: 10.1002/anie.201603928

Experimental method

X-RAY DIFFRACTION (1.82 Å)