5LJ0
Crystal structure of human ATAD2 bromodomain in complex with 8-(((3R,4R,5S)-3-((4,4-difluorocyclohexyl)methoxy)-5-methoxypiperidin-4-yl)amino)-3-methyl-5-(5-methylpyridin-3-yl)-1,7-naphthyridin-2(1H)-one
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | ATPase family AAA domain-containing protein 2 | polymer | 130 | 15453.5 | 1 | UniProt (Q6PL18) Pfam (PF00439) In PDB | Homo sapiens (Human) | AAA nuclear coregulator cancer-associated protein,ANCCA |
2 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
3 | A | 8-(((3R,4R,5S)-3-((4,4-difluorocyclohexyl)methoxy)-5-methoxypiperidin-4-yl)amino)-3-methyl-5-(5-methylpyridin-3-yl)-1,7-naphthyridin-2(1H)-one | non-polymer | 527.6 | 1 | Chemie (6XX) | |||
4 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
5 | water | water | 18.0 | 249 | Chemie (HOH) |
Sequence modifications
A: 981 - 1108 (UniProt: Q6PL18)
PDB | External Database | Details |
---|---|---|
Ser 979 | - | expression tag |
Met 980 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 15453.5 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 871.9 | |
All* | Total formula weight | 16325.5 |