5LJ0

Crystal structure of human ATAD2 bromodomain in complex with 8-(((3R,4R,5S)-3-((4,4-difluorocyclohexyl)methoxy)-5-methoxypiperidin-4-yl)amino)-3-methyl-5-(5-methylpyridin-3-yl)-1,7-naphthyridin-2(1H)-one

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006325	biological_process	chromatin organization
A	0006355	biological_process	regulation of transcription, DNA-templated
A	0016887	molecular_function	ATP hydrolysis activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue EDO A 1201

Chain	Residue
A	HIS998
A	GLU1091
A	GLU1092
A	LEU1093

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site_id	AC2
Number of Residues	6
Details	binding site for residue EDO A 1202

Chain	Residue
A	HOH1334
A	GLU988
A	GLU1092
A	ASP1094
A	PHE1097
A	HOH1313

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site_id	AC3
Number of Residues	6
Details	binding site for residue EDO A 1203

Chain	Residue
A	ARG1077
A	GLN1099
A	6XX1205
A	HOH1311
A	HOH1320
A	HOH1384

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site_id	AC4
Number of Residues	3
Details	binding site for residue EDO A 1204

Chain	Residue
A	GLN1099
A	GLU1102
A	GLU1106

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site_id	AC5
Number of Residues	15
Details	binding site for residue 6XX A 1205

Chain	Residue
A	VAL1013
A	ASP1014
A	VAL1018
A	TYR1063
A	ASN1064
A	ASP1068
A	GLY1070
A	ASP1071
A	ILE1074
A	ARG1077
A	EDO1203
A	HOH1321
A	HOH1343
A	HOH1382
A	HOH1396

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site_id	AC6
Number of Residues	8
Details	binding site for residue SO4 A 1206

Chain	Residue
A	ARG987
A	ARG990
A	ARG994
A	ARG1067
A	ARG1072
A	HOH1302
A	HOH1307
A	HOH1437

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