5LGA

Structural analysis and biological activities of BXL0124, a Gemini analog of Vitamin D

Summary for 5LGA

DescriptorVitamin D3 receptor A, SRC-2, (1~{R},3~{S},5~{Z})-5-[2-[(1~{R},3~{a}~{S},7~{a}~{R})-7~{a}-methyl-1-[(6~{R})-1,1,1-tris(fluoranyl)-10-methyl-2,10-bis(oxidanyl)-2-(trifluoromethyl)undeca-3,8-diyn-6-yl]-2,3,3~{a},5,6,7-hexahydro-1~{H}-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol, ... (4 entities in total)
Functional Keywordsvitamin d nuclear receptor, agonist, gemini, transcription
Biological sourceDanio rerio (Zebrafish)
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Cellular locationNucleus Q9PTN2
Total number of polymer chains2
Total molecular weight36099.06
Authors
Belorusova, A.Y.,Rochel, N. (deposition date: 2016-07-06, release date: 2016-10-19, Last modification date: 2017-09-20)
Primary citation
Belorusova, A.Y.,Suh, N.,Lee, H.J.,So, J.Y.,Maehr, H.,Rochel, N.
Structural analysis and biological activities of BXL0124, a gemini analog of vitamin D.
J. Steroid Biochem. Mol. Biol., 173:69-74, 2017
PubMed: 27650654 (PDB entries with the same primary citation)
DOI: 10.1016/j.jsbmb.2016.09.015
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.250508.0%10.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5lga
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Molmil generated image of 5lga
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Molmil generated image of 5lga
rotated about y axis by 90°