5LGA
Structural analysis and biological activities of BXL0124, a Gemini analog of Vitamin D
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Vitamin D3 receptor A | polymer | 300 | 33916.5 | 1 | UniProt (Q9PTN2) Pfam (PF00104) In PDB | Danio rerio (Zebrafish) | VDR-A,1,25-dihydroxyvitamin D3 receptor A,Nuclear receptor subfamily 1 group I member 1-A |
| 2 | B | SRC-2 | polymer | 13 | 1579.9 | 1 | UniProt (by SIFTS) (Q15596) In PDB | Homo sapiens | |
| 3 | A | (1~{R},3~{S},5~{Z})-5-[2-[(1~{R},3~{a}~{S},7~{a}~{R})-7~{a}-methyl-1-[(6~{R})-1,1,1-tris(fluoranyl)-10-methyl-2,10-bis(oxidanyl)-2-(trifluoromethyl)undeca-3,8-diyn-6-yl]-2,3,3~{a},5,6,7-hexahydro-1~{H}-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol | non-polymer | 602.6 | 1 | Chemie (6VH) | |||
| 4 | water | water | 18.0 | 54 | Chemie (HOH) |
Sequence modifications
A: 156 - 453 (UniProt: Q9PTN2)
| PDB | External Database | Details |
|---|---|---|
| His 154 | - | expression tag |
| Met 155 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35496.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 602.6 | |
| All* | Total formula weight | 36099.1 |
