5LAX

Crystal structure of HLA_DRB1*04:01 in complex with alpha-enolase peptide 26-40

Summary for 5LAX

• Entry DOI: 10.2210/pdb5lax/pdb
• Descriptor: HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DRB1-4 beta chain, alpha-enolase peptideTSKGLFRAAVPSGAS, ... (5 entities in total)
• Functional Keywords: hla, autoimmune desease, rheumathoid arthritis, mhc class ii, immune system
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein: P01903 P13760
• Total number of polymer chains: 6
• Total formula weight: 93034.18

Authors

Dubnovitsky, A.,Kozhukh, G.,Sandalova, T.,Achour, A. (deposition date: 2016-06-15, release date: 2016-12-07, Last modification date: 2024-01-10)

• Primary citation: Gerstner, C.,Dubnovitsky, A.,Sandin, C.,Kozhukh, G.,Uchtenhagen, H.,James, E.A.,Ronnelid, J.,Ytterberg, A.J.,Pieper, J.,Reed, E.,Tandre, C.,Rieck, M.,Zubarev, R.A.,Ronnblom, L.,Sandalova, T.,Buckner, J.H.,Achour, A.,Malmstrom, V.; Functional and Structural Characterization of a Novel HLA-DRB1*04:01-Restricted alpha-Enolase T Cell Epitope in Rheumatoid Arthritis.; Front Immunol, 7:494-494, 2016; PubMed: 27895642; DOI: 10.3389/fimmu.2016.00494

Experimental method

X-RAY DIFFRACTION (2.6 Å)