5LAX

Crystal structure of HLA_DRB1*04:01 in complex with alpha-enolase peptide 26-40

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	HLA class II histocompatibility antigen, DR alpha chain	polymer	189	21911.8	2	UniProt (P01903) Pfam (PF00993) Pfam (PF07654)	Homo sapiens (Human)	MHC class II antigen DRA
2	B, D (B, D)	HLA class II histocompatibility antigen, DRB1-4 beta chain	polymer	198	23102.7	2	UniProt (P13760) Pfam (PF00969) Pfam (PF07654) UniProt (by SIFTS) (P01911)	Homo sapiens (Human)	MHC class II antigen DRB1*4,DR4
3	E, F (E, F)	alpha-enolase peptideTSKGLFRAAVPSGAS	polymer	15	1450.6	2	UniProt (by SIFTS) (P06733)	Homo sapiens (Hhman)
4	G (D)	MALONIC ACID	non-polymer		104.1	1	Chemie (MLA)
5	H, I, J, K, L... (A, B, C, D, E...)	water	water		18.0	266	Chemie (HOH)

Sequence modifications

A, C: 1 - 181 (UniProt: P01903)

PDB	External Database	Details
Ser 182	-	expression tag
Ser 183	-	expression tag
Ala 184	-	expression tag
Asp 185	-	expression tag
Leu 186	-	expression tag
Val 187	-	expression tag
Pro 188	-	expression tag
Arg 189	-	expression tag

B, D: 1 - 190 (UniProt: P13760)

PDB	External Database	Details
Ser 191	-	expression tag
Ser 192	-	expression tag
Ala 193	-	expression tag
Asp 194	-	expression tag
Leu 195	-	expression tag
Val 196	-	expression tag
Pro 197	-	expression tag
Arg 198	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	92930.1
Non-Polymers*	Number of molecules	1
	Total formula weight	104.1
All*	Total formula weight	93034.2

*Water molecules are not included.