5L8U
Crystal Structure of BAZ2B bromodomain in complex with 3-amino-2-methylpyridine derivative 5
Summary for 5L8U
Entry DOI | 10.2210/pdb5l8u/pdb |
Related | 5E9K 5L8T |
Descriptor | Bromodomain adjacent to zinc finger domain protein 2B, ~{N}-[(1~{S})-1-(3,4-dihydro-2~{H}-1,5-benzodioxepin-7-yl)ethyl]-2-methyl-pyridin-3-amine, TRIETHYLENE GLYCOL, ... (4 entities in total) |
Functional Keywords | four helical bundle, transcription |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : Q9UIF8 |
Total number of polymer chains | 1 |
Total formula weight | 14116.27 |
Authors | Lolli, G.,Marchand, J.-R.,Caflisch, A. (deposition date: 2016-06-08, release date: 2016-10-26, Last modification date: 2024-01-10) |
Primary citation | Marchand, J.R.,Lolli, G.,Caflisch, A. Derivatives of 3-Amino-2-methylpyridine as BAZ2B Bromodomain Ligands: In Silico Discovery and in Crystallo Validation. J. Med. Chem., 59:9919-9927, 2016 Cited by PubMed: 27731638DOI: 10.1021/acs.jmedchem.6b01258 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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