5L8U

Crystal Structure of BAZ2B bromodomain in complex with 3-amino-2-methylpyridine derivative 5

Summary for 5L8U

Entry DOI	10.2210/pdb5l8u/pdb
Related	5E9K 5L8T
Descriptor	Bromodomain adjacent to zinc finger domain protein 2B, ~{N}-[(1~{S})-1-(3,4-dihydro-2~{H}-1,5-benzodioxepin-7-yl)ethyl]-2-methyl-pyridin-3-amine, TRIETHYLENE GLYCOL, ... (4 entities in total)
Functional Keywords	four helical bundle, transcription
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : Q9UIF8
Total number of polymer chains	1
Total formula weight	14116.27
Authors	Lolli, G.,Marchand, J.-R.,Caflisch, A. (deposition date: 2016-06-08, release date: 2016-10-26, Last modification date: 2024-01-10)
Primary citation	Marchand, J.R.,Lolli, G.,Caflisch, A. Derivatives of 3-Amino-2-methylpyridine as BAZ2B Bromodomain Ligands: In Silico Discovery and in Crystallo Validation. J. Med. Chem., 59:9919-9927, 2016 Cited by PubMed: 27731638 DOI: 10.1021/acs.jmedchem.6b01258 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation