5L4Q
Crystal Structure of Adaptor Protein 2 Associated Kinase 1 (AAK1) in Complex with LKB1 (AAK1 Dual Inhibitor)
Summary for 5L4Q
Entry DOI | 10.2210/pdb5l4q/pdb |
Descriptor | AP2-associated protein kinase 1, ~{N}-[5-(4-cyanophenyl)-1~{H}-pyrrolo[2,3-b]pyridin-3-yl]pyridine-3-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | kinase kinase domain, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 78706.13 |
Authors | Sorrell, F.J.,Williams, E.,Fox, N.,Abdul Azeez, K.R.,Gileadi, O.,von Delft, F.,Edwards, A.M.,Bountra, C.,Elkins, J.M.,Knapp, S. (deposition date: 2016-05-26, release date: 2016-06-08, Last modification date: 2024-01-10) |
Primary citation | Verdonck, S.,Pu, S.Y.,Sorrell, F.J.,Elkins, J.M.,Froeyen, M.,Gao, L.J.,Prugar, L.I.,Dorosky, D.E.,Brannan, J.M.,Barouch-Bentov, R.,Knapp, S.,Dye, J.M.,Herdewijn, P.,Einav, S.,De Jonghe, S. Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3- b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity. J.Med.Chem., 2019 Cited by PubMed: 31136173DOI: 10.1021/acs.jmedchem.9b00136 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.97 Å) |
Structure validation
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