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5L4Q

Crystal Structure of Adaptor Protein 2 Associated Kinase 1 (AAK1) in Complex with LKB1 (AAK1 Dual Inhibitor)

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
B0004672molecular_functionprotein kinase activity
B0005524molecular_functionATP binding
B0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues13
Detailsbinding site for residue LKB A 401
ChainResidue
AALA72
ACYS193
AASP194
AHOH529
AHOH565
ALYS74
AMET126
AASP127
APHE128
ACYS129
AGLN133
AASN136
ALEU183

site_idAC2
Number of Residues4
Detailsbinding site for residue EDO A 402
ChainResidue
AVAL86
ALYS219
ATYR220
AHOH546

site_idAC3
Number of Residues12
Detailsbinding site for residue LKB B 401
ChainResidue
BALA72
BLYS74
BMET126
BASP127
BPHE128
BCYS129
BGLY132
BGLN133
BASN136
BLEU183
BASP194
BHOH514

site_idAC4
Number of Residues4
Detailsbinding site for residue EDO B 402
ChainResidue
BPHE57
BLYS219
BTYR220
BHOH550

Functional Information from PROSITE/UniProt
site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKveNILL
ChainResidueDetails
AILE172-LEU184

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
AASP176
BASP176

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
BLEU52
BLYS74
ALEU52
ALYS74

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648
ChainResidueDetails
ATYR234
BTYR234

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
ASER235
BSER235

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:19369195
ChainResidueDetails
ATHR354
BTHR354

220472

PDB entries from 2024-05-29

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