5L4Q
Crystal Structure of Adaptor Protein 2 Associated Kinase 1 (AAK1) in Complex with LKB1 (AAK1 Dual Inhibitor)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | AP2-associated protein kinase 1 | polymer | 346 | 38951.6 | 2 | UniProt (Q2M2I8) Pfam (PF00069) In PDB | Homo sapiens (Human) | Adaptor-associated kinase 1 |
| 2 | A, B | ~{N}-[5-(4-cyanophenyl)-1~{H}-pyrrolo[2,3-b]pyridin-3-yl]pyridine-3-carboxamide | non-polymer | 339.4 | 2 | Chemie (LKB) | |||
| 3 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 4 | water | water | 18.0 | 220 | Chemie (HOH) |
Sequence modifications
A, B: 27 - 365 (UniProt: Q2M2I8)
| PDB | External Database | Details |
|---|---|---|
| Ala 366 | - | expression tag |
| Glu 367 | - | expression tag |
| Asn 368 | - | expression tag |
| Leu 369 | - | expression tag |
| Tyr 370 | - | expression tag |
| Phe 371 | - | expression tag |
| Gln 372 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 77903.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 802.8 | |
| All* | Total formula weight | 78706.1 |
